About Interleukin-12 receptor subunit beta-1
Interleukin-12 receptor subunit beta-1 (IL12RB1) is a protein
from Homo sapiens identified by UniProt accession
P42701, 662 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Interleukin-12 receptor subunit beta-1 |
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| UniProt accession | P42701 |
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| Gene | IL12RB1 |
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| Organism | Homo sapiens |
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| Length | 662 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (237)
Diseases linked to this target (Open Targets).
- tuberculosis · score 0.34
- systemic scleroderma · score 0.32
- interleukin-12 receptor subunit beta-1 measurement · score 0.27
- Oral ulcer · score 0.26
- ulcer disease · score 0.25
- liver fat measurement · score 0.23
- fat body mass · score 0.21
- body mass index · score 0.19
- genetic disorder · score 0.19
- body fat percentage · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42701-F1 | alphafold | PREDICTED | 77.52 | — |
Amino-acid sequence (662 residues)
MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA KM
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