3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)

About 3-ketoacyl-CoA thiolase, mitochondrial

3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) is a protein from Homo sapiens identified by UniProt accession P42765, 397 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.

Target properties

Protein name	3-ketoacyl-CoA thiolase, mitochondrial
UniProt accession	P42765
Gene	ACAA2
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (100)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.25
high density lipoprotein cholesterol measurement · score 0.23
Myopia · score 0.23
refractive error · score 0.23
age at onset · score 0.22
apolipoprotein A 1 measurement · score 0.19
C-reactive protein measurement · score 0.17
total cholesterol measurement · score 0.17
mean corpuscular volume · score 0.15
response to statin · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42765-F1	alphafold	PREDICTED	97.53	—

Amino-acid sequence (397 residues)

MALLRGVFVV AAKRTPFGAY GGLLKDFTAT DLSEFAAKAA LSAGKVSPET VDSVIMGNVL QSSSDAIYLA RHVGLRVGIP KETPALTINR LCGSGFQSIV NGCQEICVKE AEVVLCGGTE SMSQAPYCVR NVRFGTKLGS DIKLEDSLWV SLTDQHVQLP MAMTAENLAV KHKISREECD KYALQSQQRW KAANDAGYFN DEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQKLPPVFK KDGTVTAGNA SGVADGAGAV IIASEDAVKK HNFTPLARIV GYFVSGCDPS IMGIGPVPAI SGALKKAGLS LKDMDLVEVN EAFAPQYLAV ERSLDLDISK TNVNGGAIAL GHPLGGSGSR ITAHLVHELR RRGGKYAVGS ACIGGGQGIA VIIQSTA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards