Actin nucleation-promoting factor WAS (WAS)

About Actin nucleation-promoting factor WAS

Actin nucleation-promoting factor WAS (WAS) is a protein from Homo sapiens identified by UniProt accession P42768, 502 residues long. MolForge cross-references it against 0 known binders and 557 disease associations.

Target properties

Protein name	Actin nucleation-promoting factor WAS
UniProt accession	P42768
Gene	WAS
Organism	Homo sapiens
Length	502 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (557)

Diseases linked to this target (Open Targets).

Wiskott-Aldrich syndrome · score 0.84
X-linked thrombocytopenia with normal platelets · score 0.81
thrombocytopenia 1 · score 0.80
X-linked severe congenital neutropenia · score 0.79
Thrombocytopenia · score 0.56
constitutional neutropenia · score 0.47
lymphoma · score 0.46
genetic disorder · score 0.41
melanoma · score 0.38
Endometrial Endometrioid Adenocarcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42768-F1	alphafold	PREDICTED	69.37	—

Amino-acid sequence (502 residues)

MSGGPMGGRP GGRGAPAVQQ NIPSTLLQDH ENQRLFEMLG RKCLTLATAV VQLYLALPPG AEHWTKEHCG AVCFVKDNPQ KSYFIRLYGL QAGRLLWEQE LYSQLVYSTP TPFFHTFAGD DCQAGLNFAD EDEAQAFRAL VQEKIQKRNQ RQSGDRRQLP PPPTPANEER RGGLPPLPLH PGGDQGGPPV GPLSLGLATV DIQNPDITSS RYRGLPAPGP SPADKKRSGK KKISKADIGA PSGFKHVSHV GWDPQNGFDV NNLDPDLRSL FSRAGISEAQ LTDAETSKLI YDFIEDQGGL EAVRQEMRRQ EPLPPPPPPS RGGNQLPRPP IVGGNKGRSG PLPPVPLGIA PPPPTPRGPP PPGRGGPPPP PPPATGRSGP LPPPPPGAGG PPMPPPPPPP PPPPSSGNGP APPPLPPALV PAGGLAPGGG RGALLDQIRQ GIQLNKTPGA PESSALQPPP QSSEGLVGAL MHVMQKRSRA IHSSDEGEDQ AGDEDEDDEW DD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards