Cyclin-dependent kinase inhibitor 2A (CDKN2A)

About Cyclin-dependent kinase inhibitor 2A

Cyclin-dependent kinase inhibitor 2A (CDKN2A) is a protein from Homo sapiens identified by UniProt accession P42771, 156 residues long. MolForge cross-references it against 0 known binders and 1,777 disease associations.

Target properties

Protein name	Cyclin-dependent kinase inhibitor 2A
UniProt accession	P42771
Gene	CDKN2A
Organism	Homo sapiens
Length	156 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42771-F1	alphafold	PREDICTED	76.30	—

Amino-acid sequence (156 residues)

MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards