Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

About Cyclin-dependent kinase 4 inhibitor B

Cyclin-dependent kinase 4 inhibitor B (CDKN2B) is a protein from Homo sapiens identified by UniProt accession P42772, 138 residues long. MolForge cross-references it against 0 known binders and 601 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 4 inhibitor B
UniProt accession	P42772
Gene	CDKN2B
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (601)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.57
glioma · score 0.54
open-angle glaucoma · score 0.53
coronary artery disease · score 0.53
glioblastoma multiforme · score 0.52
type 2 diabetes mellitus · score 0.52
glaucoma · score 0.51
Parkinson disease · score 0.50
lysosomal storage disease · score 0.50
Alzheimer disease · score 0.50

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42772-F1	alphafold	PREDICTED	89.86	—

Amino-acid sequence (138 residues)

MREENKGMPS GGGSDEGLAS AAARGLVEKV RQLLEAGADP NGVNRFGRRA IQVMMMGSAR VAELLLLHGA EPNCADPATL TRPVHDAARE GFLDTLVVLH RAGARLDVRD AWGRLPVDLA EERGHRDVAG YLRTATGD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards