Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

About Cyclin-dependent kinase 4 inhibitor C

Cyclin-dependent kinase 4 inhibitor C (CDKN2C) is a protein from Homo sapiens identified by UniProt accession P42773, 168 residues long. MolForge cross-references it against 0 known binders and 329 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 4 inhibitor C
UniProt accession	P42773
Gene	CDKN2C
Organism	Homo sapiens
Length	168 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (329)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
multiple myeloma · score 0.44
medullary thyroid gland carcinoma · score 0.38
anaplastic oligodendroglioma · score 0.37
brain glioblastoma · score 0.37
glioma · score 0.34
squamous cell lung carcinoma · score 0.32
low grade glioma · score 0.31
small cell lung carcinoma · score 0.30
hepatocellular carcinoma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P42773-F1	alphafold	PREDICTED	91.85	—

Amino-acid sequence (168 residues)

MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN EVVSLMQANG AGGATNLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards