About Methylenetetrahydrofolate reductase (NADPH)
Methylenetetrahydrofolate reductase (NADPH) (MTHFR) is a protein
from Homo sapiens identified by UniProt accession
P42898, 656 residues long.
MolForge cross-references it against 0 known binders and
934 disease associations.
Target properties
| Protein name | Methylenetetrahydrofolate reductase (NADPH) |
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| UniProt accession | P42898 |
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| Gene | MTHFR |
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| Organism | Homo sapiens |
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| Length | 656 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (934)
Diseases linked to this target (Open Targets).
- homocystinuria due to methylene tetrahydrofolate reductase deficiency · score 0.86
- schizophrenia · score 0.62
- isolated spina bifida · score 0.57
- thrombophilia due to thrombin defect · score 0.50
- Global developmental delay · score 0.42
- Bilateral tonic-clonic seizure · score 0.42
- stroke · score 0.40
- Seizure · score 0.37
- Abnormality of metabolism/homeostasis · score 0.34
- Mental deterioration · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P42898-F1 | alphafold | PREDICTED | 88.65 | — |
Amino-acid sequence (656 residues)
MVNEARGNSS LNPCLEGSAS SGSESSKDSS RCSTPGLDPE RHERLREKMR RRLESGDKWF SLEFFPPRTA EGAVNLISRF DRMAAGGPLY IDVTWHPAGD PGSDKETSSM MIASTAVNYC GLETILHMTC CRQRLEEITG HLHKAKQLGL KNIMALRGDP IGDQWEEEEG GFNYAVDLVK HIRSEFGDYF DICVAGYPKG HPEAGSFEAD LKHLKEKVSA GADFIITQLF FEADTFFRFV KACTDMGITC PIVPGIFPIQ GYHSLRQLVK LSKLEVPQEI KDVIEPIKDN DAAIRNYGIE LAVSLCQELL ASGLVPGLHF YTLNREMATT EVLKRLGMWT EDPRRPLPWA LSAHPKRREE DVRPIFWASR PKSYIYRTQE WDEFPNGRWG NSSSPAFGEL KDYYLFYLKS KSPKEELLKM WGEELTSEES VFEVFVLYLS GEPNRNGHKV TCLPWNDEPL AAETSLLKEE LLRVNRQGIL TINSQPNING KPSSDPIVGW GPSGGYVFQK AYLEFFTSRE TAEALLQVLK KYELRVNYHL VNVKGENITN APELQPNAVT WGIFPGREII QPTVVDPVSF MFWKDEAFAL WIERWGKLYE EESPSRTIIQ YIHDNYFLVN LVDNDFPLDN CLWQVVEDTL ELLNRPTQNA RETEAP
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