About Neutral amino acid transporter A
Neutral amino acid transporter A (SLC1A4) is a protein
from Homo sapiens identified by UniProt accession
P43007, 532 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Neutral amino acid transporter A |
|---|
| UniProt accession | P43007 |
|---|
| Gene | SLC1A4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 532 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (138)
Diseases linked to this target (Open Targets).
- spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome · score 0.79
- genetic disorder · score 0.41
- macular telangiectasia type 2 · score 0.39
- serum metabolite measurement · score 0.39
- blood metabolite measurement · score 0.39
- Intellectual disability · score 0.37
- metabolite measurement · score 0.33
- protein measurement · score 0.32
- amino acid measurement · score 0.32
- coronary artery calcification · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43007-F1 | alphafold | PREDICTED | 80.54 | — |
Amino-acid sequence (532 residues)
MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS GVLAGAGLGA ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS GAASLDASCL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGSGAQTLQS SDLGLEDSGP PPVPKETVDS FLDLARNLFP SNLVVAAFRT YATDYKVVTQ NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL GSEGEDLIRF FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLPLILA VDWIVDRTTT VVNVEGDALG AGILHHLNQK ATKKGEQELA EVKVEAIPNC KSEEETSPLV THQNPAGPVA SAPELESKES VL
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