About Growth/differentiation factor 5
Growth/differentiation factor 5 (GDF5) is a protein
from Homo sapiens identified by UniProt accession
P43026, 501 residues long.
MolForge cross-references it against 0 known binders and
642 disease associations.
Target properties
| Protein name | Growth/differentiation factor 5 |
|---|
| UniProt accession | P43026 |
|---|
| Gene | GDF5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 501 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (642)
Diseases linked to this target (Open Targets).
- acromesomelic dysplasia 2B · score 0.77
- brachydactyly type C · score 0.76
- multiple synostoses syndrome 2 · score 0.75
- brachydactyly type A2 · score 0.75
- Acromesomelic dysplasia, Grebe type · score 0.74
- symphalangism, proximal, 1B · score 0.73
- acromesomelic dysplasia 2A · score 0.69
- acromesomelic dysplasia 2C, Hunter-Thompson type · score 0.65
- brachydactyly type A1 · score 0.61
- osteoarthritis · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43026-F1 | alphafold | PREDICTED | 69.98 | — |
Amino-acid sequence (501 residues)
MRLPKLLTFL LWYLAWLDLE FICTVLGAPD LGQRPQGTRP GLAKAEAKER PPLARNVFRP GGHSYGGGAT NANARAKGGT GQTGGLTQPK KDEPKKLPPR PGGPEPKPGH PPQTRQATAR TVTPKGQLPG GKAPPKAGSV PSSFLLKKAR EPGPPREPKE PFRPPPITPH EYMLSLYRTL SDADRKGGNS SVKLEAGLAN TITSFIDKGQ DDRGPVVRKQ RYVFDISALE KDGLLGAELR ILRKKPSDTA KPAAPGGGRA AQLKLSSCPS GRQPAALLDV RSVPGLDGSG WEVFDIWKLF RNFKNSAQLC LELEAWERGR AVDLRGLGFD RAARQVHEKA LFLVFGRTKK RDLFFNEIKA RSGQDDKTVY EYLFSQRRKR RAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
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