About Platelet-activating factor acetylhydrolase IB subunit beta
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) is a protein
from Homo sapiens identified by UniProt accession
P43034, 410 residues long.
MolForge cross-references it against 0 known binders and
281 disease associations.
Target properties
| Protein name | Platelet-activating factor acetylhydrolase IB subunit beta |
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| UniProt accession | P43034 |
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| Gene | PAFAH1B1 |
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| Organism | Homo sapiens |
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| Length | 410 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (281)
Diseases linked to this target (Open Targets).
- lissencephaly due to LIS1 mutation · score 0.82
- subcortical band heterotopia · score 0.68
- Intellectual disability · score 0.47
- classic lissencephaly · score 0.46
- genetic disorder · score 0.46
- Lissencephaly · score 0.41
- neurodegenerative disease · score 0.41
- mean platelet volume · score 0.39
- neuroticism measurement · score 0.37
- Neurodevelopmental delay · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43034-F1 | alphafold | PREDICTED | 90.25 | — |
Amino-acid sequence (410 residues)
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDVN EELDKKYAGL LEKKWTSVIR LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF SVMVSASEDA TIKVWDYETG DFERTLKGHT DSVQDISFDH SGKLLASCSA DMTIKLWDFQ GFECIRTMHG HDHNVSSVAI MPNGDHIVSA SRDKTIKMWE VQTGYCVKTF TGHREWVRMV RPNQDGTLIA SCSNDQTVRV WVVATKECKA ELREHEHVVE CISWAPESSY SSISEATGSE TKKSGKPGPF LLSGSRDKTI KMWDVSTGMC LMTLVGHDNW VRGVLFHSGG KFILSCADDK TLRVWDYKNK RCMKTLNAHE HFVTSLDFHK TAPYVVTGSV DQTVKVWECR
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