About Guanylyl cyclase-activating protein 1
Guanylyl cyclase-activating protein 1 (GUCA1A) is a protein
from Homo sapiens identified by UniProt accession
P43080, 201 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Guanylyl cyclase-activating protein 1 |
|---|
| UniProt accession | P43080 |
|---|
| Gene | GUCA1A |
|---|
| Organism | Homo sapiens |
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| Length | 201 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- cone dystrophy 3 · score 0.81
- Cone rod dystrophy · score 0.78
- Progressive cone dystrophy · score 0.75
- Retinal dystrophy · score 0.50
- Macular dystrophy · score 0.49
- cone-rod dystrophy · score 0.46
- central areolar choroidal dystrophy · score 0.38
- retinitis pigmentosa · score 0.35
- isolated macular dystrophy · score 0.34
- urate measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43080-F1 | alphafold | PREDICTED | 70.46 | — |
Amino-acid sequence (201 residues)
MGNVMEGKSV EELSSTECHQ WYKKFMTECP SGQLTLYEFR QFFGLKNLSP SASQYVEQMF ETFDFNKDGY IDFMEYVAAL SLVLKGKVEQ KLRWYFKLYD VDGNGCIDRD ELLTIIQAIR AINPCSDTTM TAEEFTDTVF SKIDVNGDGE LSLEEFIEGV QKDQMLLDTL TRSLDLTRIV RRLQNGEQDE EGADEAAEAA G
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