About Cell surface glycoprotein MUC18
Cell surface glycoprotein MUC18 (MCAM) is a protein
from Homo sapiens identified by UniProt accession
P43121, 646 residues long.
MolForge cross-references it against 0 known binders and
408 disease associations.
Target properties
| Protein name | Cell surface glycoprotein MUC18 |
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| UniProt accession | P43121 |
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| Gene | MCAM |
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| Organism | Homo sapiens |
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| Length | 646 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (408)
Diseases linked to this target (Open Targets).
- platelet count · score 0.33
- platelet crit · score 0.30
- neoplasm · score 0.12
- melanoma · score 0.11
- cancer · score 0.10
- hepatocellular carcinoma · score 0.10
- high density lipoprotein cholesterol measurement · score 0.10
- experimental autoimmune encephalomyelitis · score 0.10
- breast cancer · score 0.09
- Obesity · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43121-F1 | alphafold | PREDICTED | 80.18 | — |
Amino-acid sequence (646 residues)
MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL SQSQGNLSHV DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT LALTQVTPQD ERIFLCQGKR PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP LKEEKNRVHI QSSQTVESSG LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE VTVPVFYPTE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN DNGVLVLEPA RKEHSGRYEC QGLDLDTMIS LLSEPQELLV NYVSDVRVSP AAPERQEGSS LTLTCEAESS QDLEFQWLRE ETGQVLERGP VLQLHDLKRE AGGGYRCVAS VPSIPGLNRT QLVNVAIFGP PWMAFKERKV WVKENMVLNL SCEASGHPRP TISWNVNGTA SEQDQDPQRV LSTLNVLVTP ELLETGVECT ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH TRANSTSTER KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL PPSRKSELVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH
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