About Carnitine O-acetyltransferase
Carnitine O-acetyltransferase (CRAT) is a protein
from Homo sapiens identified by UniProt accession
P43155, 626 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | Carnitine O-acetyltransferase |
|---|
| UniProt accession | P43155 |
|---|
| Gene | CRAT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 626 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (107)
Diseases linked to this target (Open Targets).
- neurodegeneration with brain iron accumulation 8 · score 0.45
- neurodegeneration with brain iron accumulation · score 0.34
- neurodegenerative disease · score 0.30
- Parkinson disease · score 0.25
- lysosomal storage disease · score 0.25
- Alzheimer disease · score 0.25
- multiple sclerosis · score 0.25
- red blood cell density measurement · score 0.22
- Leigh syndrome · score 0.19
- low grade glioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43155-F1 | alphafold | PREDICTED | 94.62 | — |
Amino-acid sequence (626 residues)
MLAFAARTVV KPLGFLKPFS LMKASSRFKA HQDALPRLPV PPLQQSLDHY LKALQPIVSE EEWAHTKQLV DEFQASGGVG ERLQKGLERR ARKTENWLSE WWLKTAYLQY RQPVVIYSSP GVMLPKQDFV DLQGQLRFAA KLIEGVLDFK VMIDNETLPV EYLGGKPLCM NQYYQILSSC RVPGPKQDTV SNFSKTKKPP THITVVHNYQ FFELDVYHSD GTPLTADQIF VQLEKIWNSS LQTNKEPVGI LTSNHRNSWA KAYNTLIKDK VNRDSVRSIQ KSIFTVCLDA TMPRVSEDVY RSHVAGQMLH GGGSRLNSGN RWFDKTLQFI VAEDGSCGLV YEHAAAEGPP IVTLLDYVIE YTKKPELVRS PLVPLPMPKK LRFNITPEIK SDIEKAKQNL SIMIQDLDIT VMVFHHFGKD FPKSEKLSPD AFIQMALQLA YYRIYGQACA TYESASLRMF HLGRTDTIRS ASMDSLTFVK AMDDSSVTEH QKVELLRKAV QAHRGYTDRA IRGEAFDRHL LGLKLQAIED LVSMPDIFMD TSYAIAMHFH LSTSQVPAKT DCVMFFGPVV PDGYGVCYNP MEAHINFSLS AYNSCAETNA ARLAHYLEKA LLDMRALLQS HPRAKL
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