About Cathepsin O
Cathepsin O (CTSO) is a protein
from Homo sapiens identified by UniProt accession
P43234, 321 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Cathepsin O |
|---|
| UniProt accession | P43234 |
|---|
| Gene | CTSO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 321 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.35
- blood protein measurement · score 0.32
- response to paracetamol · score 0.31
- systolic blood pressure · score 0.28
- brain measurement · score 0.28
- speech perception · score 0.24
- appendicular lean mass · score 0.20
- serum gamma-glutamyl transferase measurement · score 0.16
- Cleft palate · score 0.12
- hypospadias · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43234-F1 | alphafold | PREDICTED | 89.71 | — |
Amino-acid sequence (321 residues)
MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR HRYLNSLFPS ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH MSIPNVSLPL RFDWRDKQVV TQVRNQQMCG GCWAFSVVGA VESAYAIKGK PLEDLSVQQV IDCSYNNYGC NGGSTLNALN WLNKMQVKLV KDSEYPFKAQ NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP LVVIVDAVSW QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY AHVKMGSNVC GIADSVSSIF V
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