Cathepsin K (CTSK)

About Cathepsin K

Cathepsin K (CTSK) is a protein from Homo sapiens identified by UniProt accession P43235, 329 residues long. MolForge cross-references it against 0 known binders and 678 disease associations.

Target properties

Protein name	Cathepsin K
UniProt accession	P43235
Gene	CTSK
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (678)

Diseases linked to this target (Open Targets).

pycnodysostosis · score 0.84
genetic disorder · score 0.41
osteoporosis · score 0.38
neurodegenerative disease · score 0.37
Skeletal dysplasia · score 0.36
Nail dysplasia · score 0.36
Macrocephaly · score 0.36
Increased susceptibility to fractures · score 0.36
Short stature · score 0.36
scoliosis · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43235-F1	alphafold	PREDICTED	94.87	—

Amino-acid sequence (329 residues)

MWGLKVLLLP VVSFALYPEE ILDTHWELWK KTHRKQYNNK VDEISRRLIW EKNLKYISIH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLKVPLSHS RSNDTLYIPE WEGRAPDSVD YRKKGYVTPV KNQGQCGSCW AFSSVGALEG QLKKKTGKLL NLSPQNLVDC VSENDGCGGG YMTNAFQYVQ KNRGIDSEDA YPYVGQEESC MYNPTGKAAK CRGYREIPEG NEKALKRAVA RVGPVSVAID ASLTSFQFYS KGVYYDESCN SDNLNHAVLA VGYGIQKGNK HWIIKNSWGE NWGNKGYILM ARNKNNACGI ANLASFPKM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards