About G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6 (GRK6) is a protein
from Homo sapiens identified by UniProt accession
P43250, 576 residues long.
MolForge cross-references it against 0 known binders and
268 disease associations.
Target properties
| Protein name | G protein-coupled receptor kinase 6 |
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| UniProt accession | P43250 |
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| Gene | GRK6 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (268)
Diseases linked to this target (Open Targets).
- neutrophil percentage of leukocytes · score 0.52
- hereditary angioedema type 3 · score 0.51
- congenital factor XII deficiency · score 0.51
- neurodegenerative disease · score 0.42
- lymphocyte percentage of leukocytes · score 0.36
- hereditary angioedema · score 0.34
- hypertension · score 0.34
- angioedema · score 0.34
- urticaria · score 0.34
- Hyperbilirubinemia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43250-F1 | alphafold | PREDICTED | 89.88 | — |
Amino-acid sequence (576 residues)
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVPEEYSE RFSPQARSLC SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK GQPPAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL
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