About ETS translocation variant 4
ETS translocation variant 4 (ETV4) is a protein
from Homo sapiens identified by UniProt accession
P43268, 484 residues long.
MolForge cross-references it against 0 known binders and
299 disease associations.
Target properties
| Protein name | ETS translocation variant 4 |
|---|
| UniProt accession | P43268 |
|---|
| Gene | ETV4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 484 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (299)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- prostate adenocarcinoma · score 0.38
- prostate carcinoma · score 0.37
- benign prostatic hyperplasia · score 0.37
- Prostate Small Cell Carcinoma · score 0.37
- hemangioblastoma · score 0.37
- Acinar Prostate Mucinous Adenocarcinoma · score 0.37
- Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor · score 0.37
- Acinar Prostate Adenocarcinoma, Foamy Gland Variant · score 0.37
- Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43268-F1 | alphafold | PREDICTED | 56.25 | — |
Amino-acid sequence (484 residues)
MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKPPLPYHH GEQCLYSSAY DPPRQIAIKS PAPGALGQSP LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP AVDQGGVNGH RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL LDDPTNAHFI AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR YYYEKGIMQK VAGERYVYKF VCEPEALFSL AFPDNQRPAL KAEFDRPVSE EDTVPLSHLD ESPAYLPELA GPAQPFGPKG GYSY
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