About Beta-crystallin B2
Beta-crystallin B2 (CRYBB2) is a protein
from Homo sapiens identified by UniProt accession
P43320, 205 residues long.
MolForge cross-references it against 0 known binders and
188 disease associations.
Target properties
| Protein name | Beta-crystallin B2 |
|---|
| UniProt accession | P43320 |
|---|
| Gene | CRYBB2 |
|---|
| Organism | Homo sapiens |
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| Length | 205 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (188)
Diseases linked to this target (Open Targets).
- Cataract-microcornea syndrome · score 0.77
- Cataract with Y-shaped suture opacities · score 0.51
- Total congenital cataract · score 0.51
- early-onset non-syndromic cataract · score 0.47
- Developmental cataract · score 0.45
- pulverulent cataract · score 0.39
- cerulean cataract · score 0.37
- early-onset sutural cataract · score 0.37
- early-onset nuclear cataract · score 0.37
- total early-onset cataract · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43320-F1 | alphafold | PREDICTED | 88.90 | — |
Amino-acid sequence (205 residues)
MASDHQTQAG KPQSLNPKII IFEQENFQGH SHELNGPCPN LKETGVEKAG SVLVQAGPWV GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI KVDSQEHKII LYENPNFTGK KMEIIDDDVP SFHAHGYQEK VSSVRVQSGT WVGYQYPGYR GLQYLLEKGD YKDSSDFGAP HPQVQSVRRI RDMQWHQRGA FHPSN
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