Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

About Aldehyde dehydrogenase family 3 member B1

Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) is a protein from Homo sapiens identified by UniProt accession P43353, 468 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Aldehyde dehydrogenase family 3 member B1
UniProt accession	P43353
Gene	ALDH3B1
Organism	Homo sapiens
Length	468 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
neoplasm · score 0.04
pyknoachondrogenesis · score 0.04
reticulocyte measurement · score 0.04
BMI-adjusted waist circumference · score 0.03
drug use measurement · score 0.03
esophageal squamous cell carcinoma · score 0.03
hair colour measurement · score 0.03
pachyonychia congenita · score 0.03
BMI-adjusted hip circumference · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43353-F1	alphafold	PREDICTED	96.23	—

Amino-acid sequence (468 residues)

MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards