Melanoma-associated antigen 1 (MAGEA1)

About Melanoma-associated antigen 1

Melanoma-associated antigen 1 (MAGEA1) is a protein from Homo sapiens identified by UniProt accession P43355, 309 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.

Target properties

Protein name	Melanoma-associated antigen 1
UniProt accession	P43355
Gene	MAGEA1
Organism	Homo sapiens
Length	309 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (107)

Diseases linked to this target (Open Targets).

neoplasm · score 0.08
lung adenocarcinoma · score 0.08
esophageal squamous cell carcinoma · score 0.04
laryngeal squamous cell carcinoma · score 0.04
melanoma · score 0.04
hepatocellular carcinoma · score 0.04
non-small cell lung carcinoma · score 0.04
Rheumatoid arthritis · score 0.03
Miyoshi myopathy · score 0.03
oral squamous cell carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43355-F1	alphafold	PREDICTED	74.69	—

Amino-acid sequence (309 residues)

MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA ALREEEEGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards