About Melanoma-associated antigen 2
Melanoma-associated antigen 2 (MAGEA2) is a protein
from Homo sapiens identified by UniProt accession
P43356, 314 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Melanoma-associated antigen 2 |
|---|
| UniProt accession | P43356 |
|---|
| Gene | MAGEA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 314 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- neoplasm · score 0.08
- head and neck squamous cell carcinoma · score 0.02
- cancer · score 0.02
- breast cancer · score 0.01
- embryonal carcinoma · score 0.01
- renal cell carcinoma · score 0.01
- cutaneous melanoma · score 0.01
- gastric carcinoma · score 0.01
- urinary bladder carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43356-F1 | alphafold | PREDICTED | 70.81 | — |
Amino-acid sequence (314 residues)
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL LLKYRAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEVVEVV PISHLYILVT CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS YPPLHERALR EGEE
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