About Melanoma-associated antigen 3
Melanoma-associated antigen 3 (MAGEA3) is a protein
from Homo sapiens identified by UniProt accession
P43357, 314 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Melanoma-associated antigen 3 |
|---|
| UniProt accession | P43357 |
|---|
| Gene | MAGEA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 314 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (164)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- non-small cell lung carcinoma · score 0.17
- hepatocellular carcinoma · score 0.12
- neoplasm · score 0.11
- multiple myeloma · score 0.10
- melanoma · score 0.10
- lung adenocarcinoma · score 0.08
- gonorrhea · score 0.08
- oral squamous cell carcinoma · score 0.07
- cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43357-F1 | alphafold | PREDICTED | 71.44 | — |
Amino-acid sequence (314 residues)
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAELVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASSSLQL VFGIELMEVD PIGHLYIFAT CLGLSYDGLL GDNQIMPKAG LLIIVLAIIA REGDCAPEEK IWEELSVLEV FEGREDSILG DPKKLLTQHF VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHM VKISGGPHIS YPPLHEWVLR EGEE
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