About Melanoma-associated antigen 4
Melanoma-associated antigen 4 (MAGEA4) is a protein
from Homo sapiens identified by UniProt accession
P43358, 317 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Melanoma-associated antigen 4 |
|---|
| UniProt accession | P43358 |
|---|
| Gene | MAGEA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 317 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- esophageal squamous cell carcinoma · score 0.08
- neoplasm · score 0.07
- non-small cell lung carcinoma · score 0.07
- lung adenocarcinoma · score 0.06
- melanoma · score 0.05
- cancer · score 0.05
- squamous cell carcinoma · score 0.04
- adenocarcinoma · score 0.04
- hepatocellular carcinoma · score 0.03
- skin squamous cell carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43358-F1 | alphafold | PREDICTED | 76.50 | — |
Amino-acid sequence (317 residues)
MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV IFGKASESLK MIFGIDVKEV DPASNTYTLV TCLGLSYDGL LGNNQIFPKT GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI AYPSLREAAL LEEEEGV
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