About Melanoma-associated antigen 6
Melanoma-associated antigen 6 (MAGEA6) is a protein
from Homo sapiens identified by UniProt accession
P43360, 314 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Melanoma-associated antigen 6 |
|---|
| UniProt accession | P43360 |
|---|
| Gene | MAGEA6 |
|---|
| Organism | Homo sapiens |
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| Length | 314 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- Ataxia-telangiectasia · score 0.04
- non-small cell lung carcinoma · score 0.03
- renal cell carcinoma · score 0.03
- melanoma · score 0.02
- urinary bladder carcinoma · score 0.02
- neoplasm · score 0.02
- hepatocellular carcinoma · score 0.01
- cancer · score 0.01
- squamous cell lung carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43360-F1 | alphafold | PREDICTED | 71.48 | — |
Amino-acid sequence (314 residues)
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS YPLLHEWALR EGEE
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