About Melanoma-associated antigen 8
Melanoma-associated antigen 8 (MAGEA8) is a protein
from Homo sapiens identified by UniProt accession
P43361, 318 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Melanoma-associated antigen 8 |
|---|
| UniProt accession | P43361 |
|---|
| Gene | MAGEA8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 318 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (23)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.02
- neoplasm · score 0.01
- melanoma · score 0.01
- tarsal-carpal coalition syndrome · score 0.01
- cancer · score 0.01
- esophageal squamous cell carcinoma · score 0.01
- adrenal gland pheochromocytoma · score 0.01
- Paraganglioma · score 0.01
- bladder transitional cell carcinoma · score 0.01
- breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43361-F1 | alphafold | PREDICTED | 74.56 | — |
Amino-acid sequence (318 residues)
MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL EEVTDSGSPS PPQSPEGASS SLTVTDSTLW SQSDEGSSSN EEEGPSTSPD PAHLESLFRE ALDEKVAELV RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF PDIFSKASEC MQVIFGIDVK EVDPAGHSYI LVTCLGLSYD GLLGDDQSTP KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS VYWKLRKLLT QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV RISYPSLHEE ALGEEKGV
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