About Melanoma-associated antigen 12
Melanoma-associated antigen 12 (MAGEA12) is a protein
from Homo sapiens identified by UniProt accession
P43365, 314 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Melanoma-associated antigen 12 |
|---|
| UniProt accession | P43365 |
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| Gene | MAGEA12 |
|---|
| Organism | Homo sapiens |
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| Length | 314 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- oral squamous cell carcinoma · score 0.07
- cancer · score 0.06
- hepatocellular carcinoma · score 0.05
- lung carcinoma · score 0.05
- neoplasm · score 0.04
- Ataxia-telangiectasia · score 0.03
- melanoma · score 0.02
- skin squamous cell carcinoma · score 0.02
- non-small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43365-F1 | alphafold | PREDICTED | 71.44 | — |
Amino-acid sequence (314 residues)
MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL REVPAAESPS PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD LETSFQVALS RKMAELVHFL LLKYRAREPF TKAEMLGSVI RNFQDFFPVI FSKASEYLQL VFGIEVVEVV RIGHLYILVT CLGLSYDGLL GDNQIVPKTG LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA HPRKLLTQDL VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS YPPLHEWAFR EGEE
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