About Tyrosine-protein phosphatase non-receptor type 9
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) is a protein
from Homo sapiens identified by UniProt accession
P43378, 593 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 9 |
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| UniProt accession | P43378 |
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| Gene | PTPN9 |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- cystatin C measurement · score 0.24
- type 2 diabetes mellitus · score 0.20
- body height · score 0.19
- vital capacity · score 0.14
- glomerular filtration rate · score 0.14
- forced expiratory volume · score 0.13
- testosterone measurement · score 0.12
- platelet count · score 0.12
- appendicular lean mass · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43378-F1 | alphafold | PREDICTED | 87.30 | — |
Amino-acid sequence (593 residues)
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSLAVSNMGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ
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