About Nicotinamide phosphoribosyltransferase
Nicotinamide phosphoribosyltransferase (NAMPT) is a protein
from Homo sapiens identified by UniProt accession
P43490, 491 residues long.
MolForge cross-references it against 0 known binders and
682 disease associations.
Target properties
| Protein name | Nicotinamide phosphoribosyltransferase |
|---|
| UniProt accession | P43490 |
|---|
| Gene | NAMPT |
|---|
| Organism | Homo sapiens |
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| Length | 491 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (682)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.39
- mean platelet volume · score 0.35
- neurodegenerative disease · score 0.32
- neutrophil count · score 0.29
- glomerular filtration rate · score 0.28
- protein measurement · score 0.20
- age at menopause · score 0.19
- esophageal squamous cell carcinoma · score 0.17
- melanoma · score 0.12
- type 2 diabetes mellitus · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43490-F1 | alphafold | PREDICTED | 94.22 | — |
Amino-acid sequence (491 residues)
MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR KVKYEETVFY GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG WNYILEKYDG HLPIEIKAVP EGFVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGLALIKKY YGTKDPVPGY SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV SRSTQAPLII RPDSGNPLDT VLKVLEILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT LQEIVEGMKQ KMWSIENIAF GSGGGLLQKL TRDLLNCSFK CSYVVTNGLG INVFKDPVAD PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA QLNIELEAAH H
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