About Killer cell immunoglobulin-like receptor 3DL2
Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) is a protein
from Homo sapiens identified by UniProt accession
P43630, 455 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Killer cell immunoglobulin-like receptor 3DL2 |
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| UniProt accession | P43630 |
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| Gene | KIR3DL2 |
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| Organism | Homo sapiens |
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| Length | 455 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (185)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.23
- neurodegenerative disease · score 0.21
- inflammatory bowel disease · score 0.14
- unspecified peripheral T-cell lymphoma · score 0.08
- 3-hydroxypropylmercapturic acid measurement · score 0.06
- ulcerative colitis · score 0.06
- myelodysplastic syndrome · score 0.06
- Cutaneous T-cell lymphoma · score 0.04
- cancer · score 0.04
- COVID-19 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43630-F1 | alphafold | PREDICTED | 74.93 | — |
Amino-acid sequence (455 residues)
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF
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