About Killer cell immunoglobulin-like receptor 2DS2
Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2) is a protein
from Homo sapiens identified by UniProt accession
P43631, 304 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Killer cell immunoglobulin-like receptor 2DS2 |
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| UniProt accession | P43631 |
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| Gene | KIR2DS2 |
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| Organism | Homo sapiens |
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| Length | 304 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.02
- cytomegalovirus infection · score 0.02
- cancer · score 0.02
- Vasculitis · score 0.02
- vasculitis · score 0.02
- myeloid sarcoma · score 0.02
- hepatocellular carcinoma · score 0.02
- neoplasm · score 0.02
- glioblastoma multiforme · score 0.02
- viral disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43631-F1 | alphafold | PREDICTED | 80.62 | — |
Amino-acid sequence (304 residues)
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFEHFLL HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE VSYA
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