Lysophosphatidic acid receptor 6 (LPAR6)

About Lysophosphatidic acid receptor 6

Lysophosphatidic acid receptor 6 (LPAR6) is a protein from Homo sapiens identified by UniProt accession P43657, 344 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Lysophosphatidic acid receptor 6
UniProt accession	P43657
Gene	LPAR6
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

hypotrichosis simplex · score 0.70
wooly hair, autosomal recessive 1, with or without hypotrichosis · score 0.42
Woolly hair · score 0.37
ovarian cancer · score 0.24
breast adenocarcinoma · score 0.24
thyroid gland adenocarcinoma · score 0.23
lymphocyte count · score 0.22
birth weight · score 0.20
genetic disorder · score 0.19
monocyte count · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43657-F1	alphafold	PREDICTED	84.41	—

Amino-acid sequence (344 residues)

MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN ETTTYMINLA MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP AVFVQSTHSQ GNNASEACFE NFPEATWKTY LSRIVIFIEI VGFFIPLILN VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF CFVPYNINLI LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards