26S proteasome regulatory subunit 6B (PSMC4)

About 26S proteasome regulatory subunit 6B

26S proteasome regulatory subunit 6B (PSMC4) is a protein from Homo sapiens identified by UniProt accession P43686, 418 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	26S proteasome regulatory subunit 6B
UniProt accession	P43686
Gene	PSMC4
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
lean body mass · score 0.33
breast adenocarcinoma · score 0.30
low grade glioma · score 0.29
lung adenocarcinoma · score 0.29
endometrial cancer · score 0.29
esophageal cancer · score 0.28
head and neck squamous cell carcinoma · score 0.28
squamous cell lung carcinoma · score 0.28
gastric adenocarcinoma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43686-F1	alphafold	PREDICTED	80.11	—

Amino-acid sequence (418 residues)

MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards