Transcription factor GATA-4 (GATA4)

About Transcription factor GATA-4

Transcription factor GATA-4 (GATA4) is a protein from Homo sapiens identified by UniProt accession P43694, 442 residues long. MolForge cross-references it against 0 known binders and 548 disease associations.

Target properties

Protein name	Transcription factor GATA-4
UniProt accession	P43694
Gene	GATA4
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (548)

Diseases linked to this target (Open Targets).

atrial septal defect 2 · score 0.81
ventricular septal defect 1 · score 0.79
Tetralogy of Fallot · score 0.74
atrioventricular septal defect 4 · score 0.71
congenital heart disease · score 0.66
46,XY partial gonadal dysgenesis · score 0.59
neurodegenerative disease · score 0.52
pancreatic hypoplasia-diabetes-congenital heart disease syndrome · score 0.46
familial atrial fibrillation · score 0.38
systolic blood pressure · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43694-F1	alphafold	PREDICTED	57.20	—

Amino-acid sequence (442 residues)

MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG LSYLQGGGAG SASGGASGGS SGGAASGAGP GTQQGSPGWS QAGADGAAYT PPPVSPRFSF PGTTGSLAAA AAAAAAREAA AYSSGGGAAG AGLAGREQYG RAGFAGSYSS PYPAYMADVG ASWAAAAAAS AGPFDSPVLH SLPGRANPAA RHPNLDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA CGLYHKMNGI NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAAPSGSESL PPASGASSNS SNATTSSSEE MRPIKTEPGL SSHYGHSSSV SQTFSVSAMS GHGPSIHPVL SALKLSPQGY ASPVSQSPQT SSKQDSWNSL VLADSHGDII TA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards