Elongation factor Ts, mitochondrial (TSFM)

About Elongation factor Ts, mitochondrial

Elongation factor Ts, mitochondrial (TSFM) is a protein from Homo sapiens identified by UniProt accession P43897, 325 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Elongation factor Ts, mitochondrial
UniProt accession	P43897
Gene	TSFM
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

Fatal mitochondrial disease due to combined oxidative phosphorylation deficiency 3 · score 0.78
fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3 · score 0.73
steroid-resistant nephrotic syndrome · score 0.45
nephrotic syndrome · score 0.44
genetic disorder · score 0.41
mitochondrial disease · score 0.37
neurodegenerative disease · score 0.37
dilated cardiomyopathy · score 0.33
Leigh syndrome · score 0.19
Seizure · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43897-F1	alphafold	PREDICTED	87.94	—

Amino-acid sequence (325 residues)

MSLLRSLRVF LVARTGSYPA GSLLRQSPQP RHTFYAGPRL SASASSKELL MKLRRKTGYS FVNCKKALET CGGDLKQAEI WLHKEAQKEG WSKAAKLQGR KTKEGLIGLL QEGNTTVLVE VNCETDFVSR NLKFQLLVQQ VALGTMMHCQ TLKDQPSAYS KGFLNSSELS GLPAGPDREG SLKDQLALAI GKLGENMILK RAAWVKVPSG FYVGSYVHGA MQSPSLHKLV LGKYGALVIC ETSEQKTNLE DVGRRLGQHV VGMAPLSVGS LDDEPGGEAE TKMLSQPYLL DPSITLGQYV QPQGVSVVDF VRFECGEGEE AAETE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards