About ATP-binding cassette sub-family G member 1
ATP-binding cassette sub-family G member 1 (ABCG1) is a protein
from Homo sapiens identified by UniProt accession
P45844, 678 residues long.
MolForge cross-references it against 0 known binders and
330 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family G member 1 |
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| UniProt accession | P45844 |
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| Gene | ABCG1 |
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| Organism | Homo sapiens |
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| Length | 678 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (330)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- multiple sclerosis · score 0.31
- Parkinson disease · score 0.31
- lysosomal storage disease · score 0.31
- Alzheimer disease · score 0.31
- neuritic plaque measurement · score 0.28
- high density lipoprotein cholesterol measurement · score 0.21
- birth weight · score 0.18
- endometrial cancer · score 0.17
- neuroblastoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45844-F1 | alphafold | PREDICTED | 81.12 | — |
Amino-acid sequence (678 residues)
MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN GHLKKVDNNL TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGLPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD SDHKRDLGGD AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS CLTQFCILFK RTFLSIMRDS VLTHLRITSH IGIGLLIGLL YLGIGNEAKK VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE MGVFLREHLN YWYSLKAYYL AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL GTMTSLVAQS LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL DFIVLGIFFI SLRLIAYFVL RYKIRAER
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