About Peptidyl-prolyl cis-trans isomerase C
Peptidyl-prolyl cis-trans isomerase C (PPIC) is a protein
from Homo sapiens identified by UniProt accession
P45877, 212 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase C |
|---|
| UniProt accession | P45877 |
|---|
| Gene | PPIC |
|---|
| Organism | Homo sapiens |
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| Length | 212 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.18
- high density lipoprotein cholesterol measurement · score 0.13
- bowel opening frequency · score 0.13
- diverticulitis · score 0.13
- aortic measurement · score 0.09
- coronary artery disease · score 0.09
- brain measurement · score 0.09
- neuroimaging measurement · score 0.08
- pulse pressure measurement · score 0.05
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45877-F1 | alphafold | PREDICTED | 91.51 | — |
Amino-acid sequence (212 residues)
MGPGPRLLLP LVLCVGLGAL VFSSGAEGFR KRGPSVTAKV FFDVRIGDKD VGRIVIGLFG KVVPKTVENF VALATGEKGY GYKGSKFHRV IKDFMIQGGD ITTGDGTGGV SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL TKPTWLDGKH VVFGKVIDGM TVVHSIELQA TDGHDRPLTN CSIINSGKID VKTPFVVEIA DW
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