Non-selective voltage-gated ion channel VDAC2 (VDAC2)

About Non-selective voltage-gated ion channel VDAC2

Non-selective voltage-gated ion channel VDAC2 (VDAC2) is a protein from Homo sapiens identified by UniProt accession P45880, 294 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Non-selective voltage-gated ion channel VDAC2
UniProt accession	P45880
Gene	VDAC2
Organism	Homo sapiens
Length	294 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
pancreatic adenocarcinoma · score 0.26
ovarian cancer · score 0.23
breast adenocarcinoma · score 0.23
high density lipoprotein cholesterol measurement · score 0.12
severe combined immunodeficiency · score 0.12
refractive error measurement · score 0.08
non-small cell lung carcinoma · score 0.07
self reported educational attainment · score 0.07
breast cancer · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P45880-F1	alphafold	PREDICTED	92.03	—

Amino-acid sequence (294 residues)

MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV EFSTSGSSNT DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED QICQGLKLTF DTTFSPNTGK KSGKIKSSYK RECINLGCDV DFDFAGPAIH GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF AVGYRTGDFQ LHTNVNDGTE FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP TASISAKVNN SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards