About Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB) is a protein
from Homo sapiens identified by UniProt accession
P45954, 432 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
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| UniProt accession | P45954 |
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| Gene | ACADSB |
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| Organism | Homo sapiens |
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| Length | 432 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- 2-methylbutyryl-CoA dehydrogenase deficiency · score 0.78
- genetic disorder · score 0.31
- Seizure · score 0.29
- ulcerative colitis · score 0.16
- Microcephaly · score 0.11
- attention deficit hyperactivity disorder · score 0.09
- nonpapillary renal cell carcinoma · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.06
- schizophrenia 15 · score 0.06
- uncombable hair syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45954-F1 | alphafold | PREDICTED | 91.59 | — |
Amino-acid sequence (432 residues)
MEGLAVRLLR GSRLLRRNFL TCLSSWKIPP HVSKSSQSEA LLNITNNGIH FAPLQTFTDE EMMIKSSVKK FAQEQIAPLV STMDENSKME KSVIQGLFQQ GLMGIEVDPE YGGTGASFLS TVLVIEELAK VDASVAVFCE IQNTLINTLI RKHGTEEQKA TYLPQLTTEK VGSFCLSEAG AGSDSFALKT RADKEGDYYV LNGSKMWISS AEHAGLFLVM ANVDPTIGYK GITSFLVDRD TPGLHIGKPE NKLGLRASST CPLTFENVKV PEANILGQIG HGYKYAIGSL NEGRIGIAAQ MLGLAQGCFD YTIPYIKERI QFGKRLFDFQ GLQHQVAHVA TQLEAARLLT YNAARLLEAG KPFIKEASMA KYYASEIAGQ TTSKCIEWMG GVGYTKDYPV EKYFRDAKIG TIYEGASNIQ LNTIAKHIDA EY
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