About Chromobox protein homolog 5
Chromobox protein homolog 5 (CBX5) is a protein
from Homo sapiens identified by UniProt accession
P45973, 191 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Chromobox protein homolog 5 |
|---|
| UniProt accession | P45973 |
|---|
| Gene | CBX5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 191 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (146)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.37
- alcohol consumption measurement · score 0.35
- self reported educational attainment · score 0.35
- Red cell distribution width · score 0.31
- mean corpuscular volume · score 0.30
- neurodegenerative disease · score 0.28
- body mass index · score 0.28
- platelet count · score 0.27
- cortical surface area measurement · score 0.27
- chronotype measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45973-F1 | alphafold | PREDICTED | 75.62 | — |
Amino-acid sequence (191 residues)
MGKKTKRTAD SSSSEDEEEY VVEKVLDRRV VKGQVEYLLK WKGFSEEHNT WEPEKNLDCP ELISEFMKKY KKMKEGENNK PREKSESNKR KSNFSNSADD IKSKKKREQS NDIARGFERG LEPEKIIGAT DSCGDLMFLM KWKDTDEADL VLAKEANVKC PQIVIAFYEE RLTWHAYPED AENKEKETAK S
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