About Mitogen-activated protein kinase 8
Mitogen-activated protein kinase 8 (MAPK8) is a protein
from Homo sapiens identified by UniProt accession
P45983, 427 residues long.
MolForge cross-references it against 0 known binders and
1,115 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase 8 |
|---|
| UniProt accession | P45983 |
|---|
| Gene | MAPK8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 427 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1115)
Diseases linked to this target (Open Targets).
- cancer · score 0.57
- neurodegenerative disease · score 0.37
- glioblastoma multiforme · score 0.31
- head and neck squamous cell carcinoma · score 0.29
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- lung adenocarcinoma · score 0.28
- endometrial cancer · score 0.27
- squamous cell lung carcinoma · score 0.27
- gastric adenocarcinoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45983-F1 | alphafold | PREDICTED | 82.41 | — |
Amino-acid sequence (427 residues)
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA GPLGCCR
Explore Mitogen-activated protein kinase 8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets