About Mitogen-activated protein kinase 9
Mitogen-activated protein kinase 9 (MAPK9) is a protein
from Homo sapiens identified by UniProt accession
P45984, 424 residues long.
MolForge cross-references it against 0 known binders and
336 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase 9 |
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| UniProt accession | P45984 |
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| Gene | MAPK9 |
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| Organism | Homo sapiens |
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| Length | 424 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (336)
Diseases linked to this target (Open Targets).
- cancer · score 0.56
- ovarian cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.20
- lung adenocarcinoma · score 0.19
- endometrial cancer · score 0.18
- grip strength measurement · score 0.18
- esophageal cancer · score 0.16
- small cell lung carcinoma · score 0.14
- chronic lymphocytic leukemia · score 0.13
- multiple myeloma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45984-F1 | alphafold | PREDICTED | 81.45 | — |
Amino-acid sequence (424 residues)
MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS TEQTLASDTD SSLDASTGPL EGCR
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