About Dual specificity mitogen-activated protein kinase kinase 4
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) is a protein
from Homo sapiens identified by UniProt accession
P45985, 399 residues long.
MolForge cross-references it against 0 known binders and
315 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 4 |
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| UniProt accession | P45985 |
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| Gene | MAP2K4 |
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| Organism | Homo sapiens |
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| Length | 399 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (315)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.59
- neurodegenerative disease · score 0.55
- pancreatic adenocarcinoma · score 0.49
- lysosomal storage disease · score 0.44
- pancreatic ductal adenocarcinoma · score 0.37
- Invasive Breast Carcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- esophageal adenocarcinoma · score 0.37
- anthrax infection · score 0.37
- kidney neoplasm · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P45985-F1 | alphafold | PREDICTED | 77.00 | — |
Amino-acid sequence (399 residues)
MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD
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