About 28S rRNA (cytosine(4447)-C(5))-methyltransferase
28S rRNA (cytosine(4447)-C(5))-methyltransferase (NOP2) is a protein
from Homo sapiens identified by UniProt accession
P46087, 812 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | 28S rRNA (cytosine(4447)-C(5))-methyltransferase |
|---|
| UniProt accession | P46087 |
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| Gene | NOP2 |
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| Organism | Homo sapiens |
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| Length | 812 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- glioblastoma multiforme · score 0.19
- lung adenocarcinoma · score 0.14
- Red cell distribution width · score 0.10
- endometrial cancer · score 0.10
- breast adenocarcinoma · score 0.10
- cancer · score 0.09
- nonpapillary renal cell carcinoma · score 0.08
- hepatocellular carcinoma · score 0.08
- type 2 diabetes mellitus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46087-F1 | alphafold | PREDICTED | 62.23 | — |
Amino-acid sequence (812 residues)
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS
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