G-protein coupled receptor 3 (GPR3)

About G-protein coupled receptor 3

G-protein coupled receptor 3 (GPR3) is a protein from Homo sapiens identified by UniProt accession P46089, 330 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	G-protein coupled receptor 3
UniProt accession	P46089
Gene	GPR3
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.16
primary ovarian insufficiency · score 0.07
arterial stiffness measurement · score 0.07
46,XX gonadal dysgenesis · score 0.07
isolated congenital hypogonadotropic hypogonadism · score 0.05
hypergonadotropic hypogonadism-cataract syndrome · score 0.05
Isolated follicle stimulating hormone deficiency · score 0.05
hypertension · score 0.05
premature ovarian failure 7 · score 0.05
Perrault syndrome · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46089-F1	alphafold	PREDICTED	81.84	—

Amino-acid sequence (330 residues)

MMWGAGSPLA WLSAGSGNVN VSSVGPAEGP TGPAAPLPSP KAWDVVLCIS GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAV FCIGSAEMSL VLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV TRTYVMLALV WGGALGLGLL PVLAWNCLDG LTTCGVVYPL SKNHLVVLAI AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA VVLGAFAACW LPFTVYCLLG DAHSPPLYTY LTLLPATYNS MINPIIYAFR NQDVQKVLWA VCCCCSSSKI PFRSRSPSDV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards