Chemerin-like receptor 2 (CMKLR2)

About Chemerin-like receptor 2

Chemerin-like receptor 2 (CMKLR2) is a protein from Homo sapiens identified by UniProt accession P46091, 355 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Chemerin-like receptor 2
UniProt accession	P46091
Gene	CMKLR2
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.38
CCL28 measurement · score 0.32
reticulocyte count · score 0.23
BMI-adjusted waist-hip ratio · score 0.21
chronotype measurement · score 0.16
vertebral joint disease · score 0.14
appendicular lean mass · score 0.11
monocyte count · score 0.10
body mass index · score 0.10
reticulocyte measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46091-F1	alphafold	PREDICTED	83.61	—

Amino-acid sequence (355 residues)

MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV LGIPGNAIVI WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN FHWPFGIWLC KANSFTAQLN MFASVFFLTV ISLDHYIHLI HPVLSHRHRT LKNSLIVIIF IWLLASLIGG PALYFRDTVE FNNHTLCYNN FQKHDPDLTL IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI SSRHFWTILV VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL LETAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards