G-protein coupled receptor 4 (GPR4)

About G-protein coupled receptor 4

G-protein coupled receptor 4 (GPR4) is a protein from Homo sapiens identified by UniProt accession P46093, 362 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	G-protein coupled receptor 4
UniProt accession	P46093
Gene	GPR4
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
glioblastoma multiforme · score 0.25
ovarian cancer · score 0.24
breast adenocarcinoma · score 0.24
neoplasm · score 0.10
prostate adenocarcinoma · score 0.10
hepatocellular carcinoma · score 0.07
microphthalmia with limb anomalies · score 0.07
colitis · score 0.06
head and neck squamous cell carcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46093-F1	alphafold	PREDICTED	80.68	—

Amino-acid sequence (362 residues)

MGNHTWEGCH VDSRVDHLFP PSLYIFVIGV GLPTNCLALW AAYRQVQQRN ELGVYLMNLS IADLLYICTL PLWVDYFLHH DNWIHGPGSC KLFGFIFYTN IYISIAFLCC ISVDRYLAVA HPLRFARLRR VKTAVAVSSV VWATELGANS APLFHDELFR DRYNHTFCFE KFPMEGWVAW MNLYRVFVGF LFPWALMLLS YRGILRAVRG SVSTERQEKA KIKRLALSLI AIVLVCFAPY HVLLLSRSAI YLGRPWDCGF EERVFSAYHS SLAFTSLNCV ADPILYCLVN EGARSDVAKA LHNLLRFLAS DKPQEMANAS LTLETPLTSK RNSTAKAMTG SWAATPPSQG DQVQLKMLPP AQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards