Chemokine XC receptor 1 (XCR1)

About Chemokine XC receptor 1

Chemokine XC receptor 1 (XCR1) is a protein from Homo sapiens identified by UniProt accession P46094, 333 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.

Target properties

Protein name	Chemokine XC receptor 1
UniProt accession	P46094
Gene	XCR1
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (163)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.26
breast adenocarcinoma · score 0.25
blood protein measurement · score 0.25
ulcer disease · score 0.25
COVID-19 · score 0.19
autoimmune disease · score 0.18
lymphocyte:monocyte ratio · score 0.18
eosinophil percentage of granulocytes · score 0.17
head and neck squamous cell carcinoma · score 0.17
monocyte percentage of leukocytes · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46094-F1	alphafold	PREDICTED	84.95	—

Amino-acid sequence (333 residues)

MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards