G-protein coupled receptor 6 (GPR6)

About G-protein coupled receptor 6

G-protein coupled receptor 6 (GPR6) is a protein from Homo sapiens identified by UniProt accession P46095, 362 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	G-protein coupled receptor 6
UniProt accession	P46095
Gene	GPR6
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

chronotype measurement · score 0.27
central nervous system cancer · score 0.02
mean corpuscular hemoglobin concentration · score 0.02
Parkinson disease · score 0.02
acute myeloid leukemia · score 0.01
major depressive disorder · score 0.01
neurodegenerative disease · score 0.00
insulin resistance · score 0.00
nervous system disease · score 0.00
diffuse large B-cell lymphoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46095-F1	alphafold	PREDICTED	77.56	—

Amino-acid sequence (362 residues)

MNASAASLND SQVVVVAAEG AAAAATAAGG PDTGEWGPPA AAALGAGGGA NGSLELSSQL SAGPPGLLLP AVNPWDVLLC VSGTVIAGEN ALVVALIAST PALRTPMFVL VGSLATADLL AGCGLILHFV FQYLVPSETV SLLTVGFLVA SFAASVSSLL AITVDRYLSL YNALTYYSRR TLLGVHLLLA ATWTVSLGLG LLPVLGWNCL AERAACSVVR PLARSHVALL SAAFFMVFGI MLHLYVRICQ VVWRHAHQIA LQQHCLAPPH LAATRKGVGT LAVVLGTFGA SWLPFAIYCV VGSHEDPAVY TYATLLPATY NSMINPIIYA FRNQEIQRAL WLLLCGCFQS KVPFRSRSPS EV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards