Adapter molecule crk (CRK)

About Adapter molecule crk

Adapter molecule crk (CRK) is a protein from Homo sapiens identified by UniProt accession P46108, 304 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.

Target properties

Protein name	Adapter molecule crk
UniProt accession	P46108
Gene	CRK
Organism	Homo sapiens
Length	304 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (165)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.46
systolic blood pressure · score 0.36
neurodegenerative disease · score 0.35
platelet count · score 0.34
C-reactive protein measurement · score 0.30
Agents acting on the renin-angiotensin system use measurement · score 0.30
lymphocyte percentage of leukocytes · score 0.30
breast adenocarcinoma · score 0.28
neutrophil count · score 0.27
monocyte count · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46108-F1	alphafold	PREDICTED	69.85	—

Amino-acid sequence (304 residues)

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD EDFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards