About Crk-like protein
Crk-like protein (CRKL) is a protein
from Homo sapiens identified by UniProt accession
P46109, 303 residues long.
MolForge cross-references it against 0 known binders and
252 disease associations.
Target properties
| Protein name | Crk-like protein |
|---|
| UniProt accession | P46109 |
|---|
| Gene | CRKL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 303 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (252)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- glioblastoma multiforme · score 0.29
- lung adenocarcinoma · score 0.26
- breast adenocarcinoma · score 0.25
- lymphocyte count · score 0.24
- head and neck squamous cell carcinoma · score 0.23
- endometrial cancer · score 0.18
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.10
- cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46109-F1 | alphafold | PREDICTED | 68.50 | — |
Amino-acid sequence (303 residues)
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD ENE
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